Associate Professor
Department of Human Anatomy and Cell Science
Rady Faculty of Health Sciences - Max Rady College of Medicine
University of Manitoba
Scientist Profiles G-L
Sari S Hannila, PhD
Appointments & Affiliations
Research Information
Keywords
SLPI, brain, neurodegeneration, aging, Alzheimer's
Summary
The Hannila lab studies the role of secretory leukocyte protease inhibitor (SLPI) in CNS gene expression and neurodegeneration in the aging brain. We are currently examining the ability of SLPI to suppress the expression of genes such as presenilin-1 and granulin, which are mutated in neurodegenerative diseases such as Alzheimer's disease and frontotemporal dementia. We are also conducting studies in SLPI null mutant mice to determine how the absence of SLPI alters protein expression in the CNS and how these changes affect behaviour and brain morphology with aging.
Publications
ORCID ID: https://orcid.org/0000-0002-5750-7852
Contact Information
Room 134, Basic Medical Sciences Building
745 Bannatyne Avenue
Winnipeg
Manitoba
R3E 0J9
204-789-3483
Sari.Hannila@umanitoba.ca