Scientist Profiles Q-Z

Lei Xing, PhD

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Appointments & Affiliations

Assistant Professor
Department of Biological Sciences
Faculty of Science
University of Manitoba

Children's Hospital Research Institute of Manitoba

Research Information

Cortical Development, Brain Evolution, Neural Progenitor Cells, Placenta

We study how do brains grow in different mammalian species, especially how neural stem cells are regulated by the signaling molecules from the placenta.

Expanded Summary
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The neocortex, seat of higher cognitive functions in humans, is populated by specialized neurons that are generated from neural stem cells during development. Precise temporal and spatial control of neural stem cell biology and behavior by a concert of regulatory factors is essential for the correct formation and proper function of the neocortex. Our lab is interested in understanding how do placental factors regulate the proliferation and differentiation of neural stem cells during neocortical development. We take a multidisciplinary approach, combining bioinformatic tools with cutting-edge molecular techniques and advanced microscopic imaging, to address our research question. By utilizing genetically modified mouse models and stem cell-derived 3D organoids, we aim to characterize the cellular and molecular mechanisms underlying human brain development, evolution and neurodevelopmental and neuropsychiatric disorders, such as Autism Spectrum Disorder (ASD) and schizophrenia.


Research Staff and Trainees


Contact Information

Buller Building 532B
45 Chancellors Cir
R3T 2N2

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