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Paul C. Marcogliese, PhD

Currently recruiting Graduate Students - Click here to learn more

Dr. Marcogliese accepts graduate students through the Biochemistry and Medical Genetics program. Applicants should email Dr. Marcogliese a single PDF of: -Cover letter describing why you are interested in the Marcogliese lab -CV with a section detailing all previous lab experience -Undergraduate transcripts (that include cumulative GPA - unofficial is fine)

Appointments & Affiliations

Assistant Professor
Department of Biochemistry and Medical Genetics
Rady Faculty of Health Sciences - Max Rady College of Medicine
University of Manitoba

Investigator
Children's Hospital Research Institute of Manitoba

Research Information

Keywords
Disease models, Drosophila, Functional genomics, Genetics, Molecular biology, Movement disorders, Neurobiology, Neurodegeneration, Neurodevelopment, Parkinson’s disease, Rare disease

Summary
Our focus is on studying the mechanisms underlying neurological disease. To do this, we employ strategies in model organisms to functionally assess candidate human disease variants, model disease symptoms, unravel biology, and identify & test drug leads.

Expanded Summary
Read More

I am interested in the molecular and cellular mechanisms underlying neurological disease. While the etiology of diseases like Autism Spectrum Disorder (ASD) and Parkinson’s disease is complex, the study and identification genes responsible for rare disorders can offer insight into more common conditions. We primarily use a range of techniques in Drosophila melanogaster (fruit flies) to assess the functional consequences of the patient variants in vivo. Additionally, rapid generation of Drosophila with strong loss of function alleles in these genes provides a phenotyping and screening platform for unravelling biological mechanisms and drug testing.

Publications
ORCID ID: https://orcid.org/ 0000-0002-8011-7852
GOOGLE SCHOLAR: https://scholar.google.ca/citations?hl=en&user=Zb0FlwsAAAAJ&view_op=list_works&sortby=pubdate
 PUBMED: https://pubmed.ncbi.nlm.nih.gov/?term=marcogliese+pc&sort=date

Research Staff and Trainees

Technician


Contact Information

Basic Medical Sciences Building
744 Bannatyne Ave - RM 324
Winnipeg
Manitoba
R3E 0J9
204-789-3785
Paul.Marcogliese@umanitoba.ca

Other Websites
https://www.marcoglieselab.com/

Social Media/Networking
Research Gate
Twitter