Scientist Profiles M-R

Don Miller, PhD

Currently recruiting Graduate Students - Click here to learn more

Our lab is recruiting promising graduate students interested in making impactful research discoveries. If you’d like to hear more about MSc and PhD opportunities under my supervision, please contact me by email.

Currently recruiting Postdoctoral fellows - Click here to learn more

We are seeking a highly-motivated postdoctoral fellow to join our lab. Please contact me by email to learn more.

Appointments & Affiliations

Department of Pharmacology and Therapeutics
Rady Faculty of Health Sciences - Max Rady College of Medicine
University of Manitoba

Biomedical Engineering Graduate Program, University of Manitoba

CancerCare Manitoba

Neuroscience Research Program, Winnipeg Health Sciences Centre

Research Information

Neuropharmacology, blood-brain barrier, CNS drug delivery, brain tumors

Understanding the cellular regulators of blood-brain barrier function under normal and pathophysiological conditions

Development of methods for increasing drug delivery (both small molecules and biologicals) to the brain for treatment of CNS disorders

Improving therapeutic approaches for the treatment of brain tumours

Identification of biomarkers for monitoring brain tumour response to therapy

Expanded Summary
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My research interests focus on understanding the cellular factors that control blood-brain barrier (BBB) permeability under both normal and pathophysiological conditions. Utilizing both cell culture and whole animal models, my laboratory examines various transport processes for moving drugs and solutes into and out of the brain. His research program includes examination of BBB changes during brain tumour development and identification of methods for increasing the delivery of chemotherapeutic agents to more effectively treat brain tumours; identification and characterization of drug efflux transport proteins in the blood-brain barrier and the molecular mechanisms influencing their activity and expression; and the design and development of nanoparticle drug delivery platforms for treating CNS diseases. My laboratory has also examined inflammatory processes including cytokine and lipid mediators of inflammation and their impact on brain endothelial response and has recently expanded into inflammatory cascades in other organ/tissues including chondrocytes (joint related inflammation) and microglia/macrophage (CNS and systemic inflammation).

Research Staff and Trainees
Vinith Yathindranath
Research Associate

Stacey Line
Graduate Student

Nur Safa
Graduate Student

Prasanta Paul
Postdoctoral Fellow

Contact Information

710 William Avenue

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