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Scientist Profiles A-F
Renee Nicole Douville, PhD
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Appointments & Affiliations
Professor
Department of Biology
Faculty of Science
University of Winnipeg
Principal Investigator
St. Boniface Hospital Research, Division of Neurodegenerative Disorders
Pharmacology and Therapeutics
University of Manitoba, Other Program
Research Information
Keywords
Endogenous retrovirus, Neurodegenerative disease, Amyotrophic Lateral Sclerosis (ALS), Dementia, innate immunity, inflammation
Summary
With growing evidence of how human endogenous retrovirus-K (ERVK / HERV-K) proteins deregulate cellular processes and drive pathologic motor neuron death, our research substantially shifts current paradigms on neurodegeneration in ALS. The molecular changes induced by ERVK have important implications for defining the pathophysiology of virus-mediated motor neuron loss in ALS and warrant further investigation. The broad long-term objective of this research direction is to lay the biomedical foundation for the use of anti-retroviral therapeutics in ALS, and other ERVK-associated conditions.
Publications
PUBMED: https://pubmed.ncbi.nlm.nih.gov/?term=Douville+R&sort=date
Contact Information
St. Boniface Hospital Albrechtsen Research Centre
351 Taché Ave, Lab 4050
Winnipeg
Manitoba
R2H 2A6
204-235-3942
r.douville@uwinnipeg.ca
Other Websites
https://www.uwinnipeg.ca/biology/people/faculty-staff/renee-douville.html
http://www.sbrc.ca/douville/